Ofloxacin is used for the management of as broad-spectrum antibiotic so effective against of gram positive and negative bacteria. The design of the delivery was based on the sustained release formulation with floating and swelling features in order to prolong gastric retention time of the drug delivery systems. Therefore, the present investigation was concerned with the development of the floating matrix tablets, which after oral administration were designed to prolong the gastric residence time by floating behavior and thus to increase the bioavailability of the drug and its half life. Different polymers such as psyllium husk (natural polymer) and HPMC (hydrophilic polymer) used in formulations. Various formulations of dose 200 mg were developed by using release rate controlling polymers like HPMC, gelling agent like psyllium husk and gas generating ingredients like NaHCO3 by wet granulation method. . All the formulations had floating lag time of below 4 min and constantly for longer period of time (more than 12 hrs). Swelling studies indicated significant water uptake which contributed in drug release. Formulation F5 containing 1:1 ratio of HPMC and psyllium husk respectively was the best formulation on basis evaluated parameter. The best formulations followed power law kinetics while the drug release mechanism was found to be anomalous type, diffusion through the honeycomb network and polymer relaxation. Thus, best formulations satisfied physicochemical parameters, floating time and in vitro drug release profile requirements for FDDs.
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